Sally N Adebamowo, Donna Spiegelman, Walter C Willett, Kathryn Meters Rexrode, Relationship anywhere between consumption of magnesium, potassium, and you can calcium supplements and you can chance of coronary arrest: dos cohorts people girls and you will current meta-analyses, The latest Western Diary of Systematic Nourishment, Regularity 101, Issue 6, , Pages 1269–1277,
Abstract
Background: Prospective analysis toward family from magnesium, potassium, and calcium consumption with stroke chance try contradictory, in order to our very own degree, the result away from a combined nutrient diet rating hasn’t been checked.
Objective: We tested associations ranging from consumption of magnesium, potassium, and you will calcium supplements and you may risk of incident coronary arrest inside 86,149 women in this new Nurses’ Health Research (NHS) We and you may 94,715 ladies in the new NHS II.
Design: Within possible cohort analysis, we computed Time out of heart attack because of the quintiles from intake per nutrient as well as a combined diet rating of the many step 3 nutritional elements by using multivariate Cox proportional possibilities activities. Additionally, i up-to-date meta-analyses on fat reduction consumption ones nutrients and chance of heart attack.
Results: Throughout the pursue-up (30 y throughout the NHS I; twenty two y throughout the NHS II) a maximum of 3780 experience coronary attack times was basically recorded. Pooled multivariate RRs out-of complete coronary attack for women regarding the higher in contrast to a decreased quintiles was basically 0.87 (95% CI: 0.78, 0.97) having full magnesium, 0.89 (95% CI: 0.80, 0.99) to possess full potassium, and you will 0.97 (95% CI: 0.87, step one.09) to own total calcium supplements consumption. Pooled RRs for ladies regarding the large compared with a low quintiles out of a mixed nutrient eating plan rating was indeed 0.72 (95% CI: 0.65, 0.81) to have full coronary attack, 0.78 (95% CI: 0.66, 0.92) to possess ischemic coronary attack, and 0.80 (95% CI: 0.61, step 1.04) for hemorrhagic stroke. In the current meta-analyses of all possible training up to now, the fresh new shared RR regarding overall coronary arrest are 0.87 (95% CI: 0.83, 0.92) for a 100-mg/d rise in magnesium intake, 0.91 (95% CI: 0.88, 0.94) to possess an effective one thousand-mg/d upsurge in potassium intake, and 0.98 (95% CI: 0.94, 1.02) for a 3 hundred-mg/d upsurge in calcium supplements consumption.
Conclusions: 
A mixed nutrient eating plan rating was inversely of the likelihood of coronary arrest. Highest intakes out-of magnesium and you may potassium however calcium supplements was in fact in addition to significantly of this faster danger of stroke in women.
Inclusion
Magnesium is a vital nutrient and you will cofactor for >three hundred enzymatic responses in your body ( 1). Magnesium is the 2nd extremely-numerous intracellular cation next to potassium ( 2). Calcium supplements is among the most-abundant nutrient in the body. Particularly magnesium and you will potassium, calcium is vitally in cardiovascular characteristics ( 3). Highest losing weight intakes of each of those vitamins were reported to help you all the way down chance of blood pressure levels ( 4– 7), the prominent modifiable stroke chance foundation. not, not absolutely all possible studies looked at the fresh new relation between slimming down and supplemental intakes of those nutritional elements and you can chance of stroke in women, and performance have been inconsistent. Possible education inside European countries demonstrated magnesium intake, although not consumption off potassium otherwise calcium supplements, try somewhat associated with the less risk of coronary attack ( eight, 8). In the usa, intakes regarding potassium and you will magnesium, not of calcium supplements, was indeed regarding the shorter heart attack chance for the guys ( 9), while calcium supplements and you will potassium consumption, yet not magnesium consumption, was indeed in the smaller coronary arrest chance in women ( 10). Plus, one to studies presented zero total relationship anywhere between some of these nutrients and you will danger of heart attack ( 11).
Some of the potential observational degree that have been held failed to tend to be follow-up past fifteen y together with a fairly small number of event coronary arrest events, as well as in very studies, brand new separate effectation of for each and every mineral consumption from pills and you may stroke sizes was not checked. In this post, we offer facts into organization of each and every mineral intake from diet and capsules having danger of complete, ischemic, and you may hemorrhagic event shots. Simultaneously, we hypothesized you to a blended diet rating of all the 3 vitamins tends to be in the faster coronary attack exposure because these minerals exist together in the meals, and you will consumption is strongly correlated. We handled such aims into the Us women that have been accompanied prospectively from the dos highest cohorts this new Nurses’ Fitness Studies (NHS) 5 I and II.
